Beneficial effects of perioperative statins for major pulmonary resection.

ABSTRACT:

Objectives

Statins improve overall outcomes after noncardiac surgery. The primary aim of the study was to determine whether use of perioperative atorvastatin reduced the rate of postoperative complications in patients undergoing pulmonary resection.

Methods

This was a prospective, randomized, placebo-controlled, double-blind trial of patients undergoing elective pulmonary resection who received atorvastatin (40 mg daily) or placebo beginning 1 week before surgery and continued for 1 week postoperatively. Patient characteristics and postoperative complications were recorded. Plasma inflammatory markers were sampled at baseline, in the post-anesthesia care unit, and on postoperative day 3. Because of difficulty enrolling statin-naive patients, the study was stopped at the inte

SUBMITTER: Amar D 

PROVIDER: S-EPMC4758508 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature