Ontology highlight
ABSTRACT:
SUBMITTER: Pfirschke C
PROVIDER: S-EPMC4758865 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Immunity 20160209 2
Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung adenocarcinoma mouse models, including genetic models, we show that autochthonous tumors that lacked T cell infiltration and resisted current treatment options could be successfully sensitized to host antitumor T cell immunity when appropriately selected immunogenic drugs (e.g., oxaliplatin combined with cyclophosphami ...[more]