Novel Genetic Loci Associated With Retinal Microvascular Diameter.

ABSTRACT:

Background

There is increasing evidence that retinal microvascular diameters are associated with cardiovascular and cerebrovascular conditions. The shared genetic effects of these associations are currently unknown. The aim of this study was to increase our understanding of the genetic factors that mediate retinal vessel size.

Methods and results

This study extends previous genome-wide association study results using 24 000+ multiethnic participants from 7 discovery cohorts and 5000+ subjects of European ancestry from 2 replication cohorts. Using the Illumina HumanExome BeadChip, we investigate the association of single-nucleotide polymorphisms and variants collectively across genes with summary measures of retinal vessel diameters, referred to as the central retinal venule

SUBMITTER: Jensen RA 

PROVIDER: S-EPMC4758888 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature