A Polymorphism in the FGFR4 Gene Is Associated With Risk of Neuroblastoma and Altered Receptor Degradation.

ABSTRACT:

Background

Outcomes for children with high-risk neuroblastoma are poor, and improved understanding of the mechanisms underlying neuroblastoma pathogenesis, recurrence, and treatment resistance will lead to improved outcomes. Aberrant growth factor receptor expression and receptor tyrosine kinase signaling are associated with the pathogenesis of many malignancies. A germline polymorphism in the FGFR4 gene is associated with increased receptor expression and activity and with decreased survival, treatment resistance, and aggressive disease for many malignancies. We therefore investigated the role of this FGFR4 polymorphism in neuroblastoma pathogenesis.

Materials and methods

Germline DNA from neuroblastoma patients and matched controls was assessed for the FGFR4 Gly/Arg388 pol

SUBMITTER: Whittle SB 

PROVIDER: S-EPMC4758892 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature