Quantitative theory for the longitudinal relaxation time of blood water.

ABSTRACT:

Purpose

To propose and evaluate a model for the blood water T1 that takes into account the effects of hematocrit fraction, oxygenation fraction, erythrocyte hemoglobin concentration, methemoglobin fraction, and plasma albumin concentration.

Methods

Whole blood and lysed blood T1 data were acquired at magnetic fields of 3 Tesla (T), 7T, 9.4T, and 11.7T using inversion-recovery measurements and a home-built blood circulation system for maintaining physiological conditions. A quantitative model was derived based on multivariable fitting of this data.

Results

Fitting of the model to the data allowed determination of the different parameters describing the blood water T1 such as those for the diamagnetic and paramagnetic effects of albumin and hemoglobin, and the contribut

SUBMITTER: Li W 

PROVIDER: S-EPMC4758918 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature