Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls.

ABSTRACT:

Background

Vitamin D insufficiency is a risk factor for multiple sclerosis (MS), and patients do not always show the expected response to vitamin D supplementation.

Objective

We aimed to determine if vitamin D supplementation leads to a similar increase in serum 25-hydroxyvitamin-D (25(OH)D) levels in patients with MS and healthy controls (HCs).

Methods

Participants in this open-label study were female, white, aged 18-60 years, had 25(OH)D levels ⩽ 75 nmol/l at screening, and had relapsing-remitting MS (RRMS) or were HCs. Participants received 5000 IU/day of vitamin D3 for 90 days. Utilizing generalized estimating equations we examined the relationship between the primary outcome (serum 25(OH)D level) and the primary (MS versus HC status) and secondary predictors.

SUBMITTER: Bhargava P 

PROVIDER: S-EPMC4758937 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature