Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model.

ABSTRACT: Rational design of multi-targeted drug combinations is a promising strategy to tackle the drug resistance problem for many complex disorders. A drug combination is usually classified as synergistic or antagonistic, depending on the deviation of the observed combination response from the expected effect calculated based on a reference model of non-interaction. The existing reference models were proposed originally for low-throughput drug combination experiments, which make the model assumptions often incompatible with the complex drug interaction patterns across various dose pairs that are typically observed in large-scale dose-response matrix experiments. To address these limitations, we proposed a novel reference model, named zero interaction potency (ZIP), which captures the drug interac

SUBMITTER: Yadav B 

PROVIDER: S-EPMC4759128 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature