Prognostic significance of aromatase and estrogen receptor beta expression in EGFR wild-type lung adenocarcinoma.

ABSTRACT:

Objectives

Based on recent findings of aromatase and estrogen receptor beta (ERβ) expression in non-small-cell lung cancer, we assessed the clinicopathological and prognostic significance of aromatase and ERβ expression and their relationship to epidermal growth factor receptor (EGFR) mutation in lung adenocarcinoma.

Materials and methods

We evaluated 150 resected primary lung adenocarcinoma specimens. Expression of aromatase, ERα, ERβ, progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) was evaluated by immunostaining, and EGFR and KRAS mutations were analyzed. Overall survival (OS) and recurrence-free survival (RFS) were calculated using the Kaplan-Meier method.

Results

Expression of aromatase, ERα, ERβ, PR, and HER2 was detected in 88.0%

SUBMITTER: Tanaka K 

PROVIDER: S-EPMC4759418 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature