Pharmacokinetics of oral and intravenous melatonin in healthy volunteers.

ABSTRACT:

Background

The aim was to investigate the pharmacokinetics of oral and iv melatonin in healthy volunteers.

Methods

The study was performed as a cohort crossover study. The volunteers received either 10 mg oral melatonin or 10 mg intravenous melatonin on two separate study days. Blood samples were collected at different time points following oral administration and short iv infusion, respectively. Plasma melatonin concentrations were determined by RIA technique. Pharmacokinetic analyses were performed by "the method of residuals" and compartmental analysis. The pharmacokinetic variables: k a, t 1/2 absorption, t max, C max, t 1/2 elimination, AUC 0-∞, and bioavailability were determined for oral melatonin. C max, t 1/2 elimination, V d, CL and AUC 0-∞ were determined for intr

SUBMITTER: Andersen LP 

PROVIDER: S-EPMC4759723 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature