On the organization of human T-cell receptor loci: log-periodic distribution of T-cell receptor gene segments.

ABSTRACT: The human T-cell repertoire is complex and is generated by the rearrangement of variable (V), diversity (D) and joining (J) segments on the T-cell receptor (TCR) loci. The T-cell repertoire demonstrates self-similarity in terms clonal frequencies when defined by V, D and J gene segment usage; therefore to determine whether the structural ordering of these gene segments on the TCR loci contributes to the observed clonal frequencies, the TCR loci were examined for self-similarity and periodicity in terms of gene segment organization. Logarithmic transformation of numeric sequence order demonstrated that the V and J gene segments for both T-cell receptor α (TRA) and β (TRB) loci are arranged in a self-similar manner when the spacing between the adjacent segments was considered as a function o

SUBMITTER: Toor AA 

PROVIDER: S-EPMC4759796 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature