A block mixture model to map eQTLs for gene clustering and networking.

ABSTRACT: To study how genes function in a cellular and physiological process, a general procedure is to classify gene expression profiles into categories based on their similarity and reconstruct a regulatory network for functional elements. However, this procedure has not been implemented with the genetic mechanisms that underlie the organization of gene clusters and networks, despite much effort made to map expression quantitative trait loci (eQTLs) that affect the expression of individual genes. Here we address this issue by developing a computational approach that integrates gene clustering and network reconstruction with genetic mapping into a unifying framework. The approach can not only identify specific eQTLs that control how genes are clustered and organized toward biological functions, bu

SUBMITTER: Wang N 

PROVIDER: S-EPMC4759821 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature