Feline panleukopenia virus in cerebral neurons of young and adult cats.

ABSTRACT:

Background

Perinatal infections with feline panleukopenia virus (FPV) have long been known to be associated with cerebellar hypoplasia in kittens due to productive infection of dividing neuroblasts. FPV, like other parvoviruses, requires dividing cells to replicate which explains the usual tropism of the virus for the digestive tract, lymphoid tissues and bone marrow in older animals.

Results

In this study, the necropsy and histopathological analyses of a series of 28 cats which died from parvovirus infection in 2013 were performed. Infections were confirmed by real time PCR and immunohistochemistry in several organs. Strikingly, while none of these cats showed cerebellar atrophy or cerebellar positive immunostaining, some of them, including one adult, showed a bright positi

SUBMITTER: Garigliany M 

PROVIDER: S-EPMC4759964 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature