Population Structure Shapes Copy Number Variation in Malaria Parasites.

ABSTRACT: If copy number variants (CNVs) are predominantly deleterious, we would expect them to be more efficiently purged from populations with a large effective population size (Ne) than from populations with a small Ne. Malaria parasites (Plasmodium falciparum) provide an excellent organism to examine this prediction, because this protozoan shows a broad spectrum of population structures within a single species, with large, stable, outbred populations in Africa, small unstable inbred populations in South America and with intermediate population characteristics in South East Asia. We characterized 122 single-clone parasites, without prior laboratory culture, from malaria-infected patients in seven countries in Africa, South East Asia and South America using a high-density single-nucleotide polymor

SUBMITTER: Cheeseman IH 

PROVIDER: S-EPMC4760083 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature