Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications.

ABSTRACT:

Background

Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic nature of the particles can be an important design criterion to ensure selective surface modification or independent release of combinations of drugs.

Purpose

Electrohydrodynamic (EHD) co-jetting is used for the fabrication of uniform anisotropic nanoparticles with individual compartments and initial physicochemical and biological characterization is reported.

Methods

EHD co-jetting is used to create nanoparticles, which are characterized at each stage with scanning electron microscopy (SEM), structured illumination microscopy (SIM), dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Surface

SUBMITTER: Rahmani S 

PROVIDER: S-EPMC4760101 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature