Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog.

ABSTRACT: Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene, but the latter displayed increased azole minimum inhibitory concentrations. A novel frameshift mutation in ERG3 was found in some isolates recovered after resistance development, so it appears unlikely that this mutation is responsible for multi-azole resistance.

SUBMITTER: Alvarez-Perez S 

PROVIDER: S-EPMC4760230 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature