PD-1 expression conditions T cell avidity within an antigen-specific repertoire.

ABSTRACT: Despite its negative regulatory role on tumor-specific T cells, Programmed cell death 1 (PD-1) is also a marker of activated tumor-infiltrating T cells. In cancer, PD-1 blockade partially reverses T cell dysfunction allowing the amplification of tumor reactive T cells. Here, we investigated the role of PD-1 signaling on effector/memory human T cells specific for shared melanoma antigens, derived from blood. We documented for the first time the existence of melanoma-specific T cell clones unable to express PD-1. This stable feature was due to the persistent methylation of the PDCD1 promoter. These PD-1^neg clones were of lower avidity than their PD-1^pos counterparts, suggesting that high-affinity-specific T cell clones unable to express PD-1 are not or rarely pre

SUBMITTER: Simon S 

PROVIDER: S-EPMC4760290 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature