Comparison of naive and central memory derived CD8⁺ effector cell engraftment fitness and function following adoptive transfer.

ABSTRACT: Human CD8⁺ effector T cells derived from CD45RO⁺CD62L⁺ precursors enriched for central memory (T_CM) precursors retain the capacity to engraft and reconstitute functional memory upon adoptive transfer, whereas effectors derived from CD45RO⁺CD62L^- precursors enriched for effector memory precursors do not. Here we sought to compare the engraftment fitness and function of CD8⁺ effector T cells derived from CD45RA⁺CD62L⁺ precursors enriched for naïve and stem cell memory precursors (T_N/SCM) with that of T_CM. We found that cytotoxic T cells (CTLs) derived from T_CM transcribed higher levels of CD28, FOS, INFγ, Eomesodermin (Eomes), and lower levels of BCL2L11, mainta

SUBMITTER: Wang X 

PROVIDER: S-EPMC4760301 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature