Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype.

ABSTRACT:

Background and purpose

Elevated plasma homocysteine levels are associated with stroke. However, this might be a reflection of bias or confounding because trials have failed to demonstrate an effect from homocysteine lowering in stroke patients, although a possible benefit has been suggested in lacunar stroke. Genetic studies could potentially overcome these issues because genetic variants are inherited randomly and are fixed at conception. Therefore, we tested the homocysteine levels-associated genetic variant MTHFR C677T for association with magnetic resonance imaging-confirmed lacunar stroke and compared this with associations with large artery and cardioembolic stroke subtypes.

Methods

We included 1359 magnetic resonance imaging-confirmed lacunar stroke cases, 1824 large

SUBMITTER: Rutten-Jacobs LC 

PROVIDER: S-EPMC4760380 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature