Partner Human Papillomavirus Viral Load and Incident Human Papillomavirus Detection in Heterosexual Couples.

ABSTRACT:

Background

The association between partner human papillomavirus (HPV) viral load and incident HPV detection in heterosexual couples is unknown.

Methods

HPV genotypes were detected in 632 human immunodeficiency virus (HIV)-negative couples followed for 2 years in a male circumcision trial in Rakai, Uganda, using the Roche HPV Linear Array. This assay detects 37 genotypes and provides a semiquantitative measure of viral load based on the intensity (graded 1-4) of the genotype-specific band; a band intensity of 1 indicates a low genotype-specific HPV load, whereas an intensity of 4 indicates a high load. Using Poisson regression with generalized estimating equations, we measured the association between partner's genotype-specific viral load and detection of that genotype in the

SUBMITTER: Grabowski MK 

PROVIDER: S-EPMC4760424 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature