Phase II trial of bevacizumab and erlotinib as a second-line therapy for advanced hepatocellular carcinoma.

ABSTRACT:

Trial registry

Clinicaltrials.gov #NCT01180959.

Background

Early clinical studies of bevacizumab and erlotinib in advanced hepatocellular carcinoma (HCC) have a tolerable toxicity and a promising clinical outcome. We evaluated the efficacy and tolerability of this combination as a second-line therapy for HCC refractory to sorafenib.

Methods

For this single-arm, Phase II study, we recruited patients with Child-Pugh class A or B liver disease, Eastern Cooperative Oncology Group performance status 0-2, and advanced HCC that was not amenable to surgical or regional therapies and treatment with sorafenib had failed (disease progressed or patient could not tolerate sorafenib). Patients received 10 mg/kg intravenous bevacizumab every 14 days and 150 mg oral erlotinib daily f

SUBMITTER: Kaseb AO 

PROVIDER: S-EPMC4760665 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature