Multiscale approach to investigate self-assembly of telodendrimer based nanocarriers for anticancer drug delivery.

ABSTRACT: Delivery of poorly soluble anticancer drugs can be achieved by employing polymeric drug delivery systems, capable of forming stable self-assembled nanocarriers with drug encapsulated within their hydrophobic cores. Computational investigations can aid the design of efficient drug-delivery platforms; however, simulations of nanocarrier self-assembly process are challenging due to high computational cost associated with the large system sizes (millions of atoms) and long time scales required for equilibration. In this work, we overcome this challenge by employing a multiscale computational approach in conjunction with experiments to analyze the role of the individual building blocks in the self-assembly of a highly tunable linear poly(ethylene glycol)-b-dendritic oligo(cholic acid) block cop

SUBMITTER: Jiang W 

PROVIDER: S-EPMC4760677 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature