Agent Based Modeling of Human Gut Microbiome Interactions and Perturbations.

ABSTRACT:

Background

Intestinal microbiota plays an important role in the human health. It is involved in the digestion and protects the host against external pathogens. Examination of the intestinal microbiome interactions is required for understanding of the community influence on host health. Studies of the microbiome can provide insight on methods of improving health, including specific clinical procedures for individual microbial community composition modification and microbiota correction by colonizing with new bacterial species or dietary changes.

Methodology/principal findings

In this work we report an agent-based model of interactions between two bacterial species and between species and the gut. The model is based on reactions describing bacterial fermentation of polysacchar

SUBMITTER: Shashkova T 

PROVIDER: S-EPMC4760737 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature