Lack of endogenous cholecystokinin promotes cholelithogenesis in mice.

ABSTRACT:

Background

Celiac disease is an autoimmune enteropathy caused by a permanent intolerance to dietary gluten in genetically predisposed individuals. Cholecystokinin (CCK) release from the proximal small intestine and gallbladder emptying in response to a fatty meal are greatly reduced in celiac patients before they start the gluten-free diet, showing a genetic predisposition to gallstones.

Methods

To elucidate the complex pathophysiological mechanisms determining the biliary characteristic of celiac disease, we investigated the effect of the absence of endogenous CCK on cholesterol crystallization and gallstone formation in mice fed a lithogenic diet for 28 days.

Key results

Fasting gallbladder volumes were increased and the response of gallbladder emptying to the high-

SUBMITTER: Wang HH 

PROVIDER: S-EPMC4760924 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature