Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines.

ABSTRACT: The robustness of immune responses to an antigen could be dictated by the route of vaccine inoculation. Traditional smallpox vaccines, essentially vaccinia virus strains, that were used in the eradication of smallpox were administered by percutaneous inoculation (skin scarification). The modified vaccinia virus Ankara is licensed as a smallpox vaccine in Europe and Canada and currently undergoing clinical development in the United States. MVA is also being investigated as a vector for the delivery of heterologous genes for prophylactic or therapeutic immunization. Since MVA is replication-deficient, MVA and MVA-vectored vaccines are often inoculated through the intramuscular, intradermal or subcutaneous routes. Vaccine inoculation via the intramuscular, intradermal or subcutaneous routes r

SUBMITTER: Meseda CA 

PROVIDER: S-EPMC4760941 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature