Premature coronary heart disease and autosomal dominant hypercholesterolemia: Increased risk in women with LDLR mutations.

ABSTRACT:

Background

For patients with autosomal dominant hypercholesterolemia (ADH), it remains unclear whether differences exist in the risk of premature coronary heart disease (CHD) between patients with confirmed mutations in low-density lipoprotein receptor (LDLR) vs those without detectable mutations.

Objective

This study sought to assess the risk of premature CHD in ADH patients with mutations in LDLR (referred to as familial hypercholesterolemia [FH]) vs those without detectable mutations (unexplained ADH), stratified by sex.

Methods

Comparative study of premature CHD in a multiethnic cohort of 111 men and 165 women meeting adult Simon-Broome criteria for ADH.

Results

Women with FH (n = 51) had an increased risk of premature CHD compared with unexplained ADH wome

SUBMITTER: Ahmad Z 

PROVIDER: S-EPMC4761103 | biostudies-literature | 2016 Jan-Feb

REPOSITORIES: biostudies-literature