Hereditary melanoma: Update on syndromes and management: Emerging melanoma cancer complexes and genetic counseling.

ABSTRACT: Recent advances in cancer genomics have enabled the discovery of many cancer-predisposing genes that are being used to classify new familial melanoma/cancer syndromes. In addition to CDKN2A and CDK4, germline variants in TERT, MITF, and BAP1 have been added to the list of genes harboring melanoma-predisposing mutations. These newer entities may have escaped earlier description in part because of more advanced technologies now being used and in part because of their mixed cancer phenotype as opposed to a melanoma-focused syndrome. Dermatologists should be aware of (and be able to recognize) the clinical signs in high-risk patients in different contexts. Personal and family histories of cancer should always be sought in patients with multiple nevi or a positive history for melanoma, and shou

SUBMITTER: Soura E 

PROVIDER: S-EPMC4761106 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature