Cellular reprogramming in farm animals: an overview of iPSC generation in the mammalian farm animal species.

ABSTRACT: Establishment of embryonic stem cell (ESC) lines has been successful in mouse and human, but not in farm animals. Development of direct reprogramming technology offers an alternative approach for generation of pluripotent stem cells, applicable also in farm animals. Induced pluripotent stem cells (iPSCs) represent practically limitless, ethically acceptable, individuum-specific source of pluripotent cells that can be generated from different types of somatic cells. iPSCs can differentiate to all cell types of an organism's body and have a tremendous potential for numerous applications in medicine, agriculture, and biotechnology. However, molecular mechanisms behind the reprogramming process remain largely unknown and hamper generation of bona fide iPSCs and their use in human clinical prac

SUBMITTER: Ogorevc J 

PROVIDER: S-EPMC4761155 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature