Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial.

ABSTRACT:

Background

Periodontitis, which progressively destroys tooth-supporting structures, is one of the most widespread infectious diseases and the leading cause of tooth loss in adults. Evidence from preclinical trials and small-scale pilot clinical studies indicates that stem cells derived from periodontal ligament tissues are a promising therapy for the regeneration of lost/damaged periodontal tissue. This study assessed the safety and feasibility of using autologous periodontal ligament stem cells (PDLSCs) as an adjuvant to grafting materials in guided tissue regeneration (GTR) to treat periodontal intrabony defects. Our data provide primary clinical evidence for the efficacy of cell transplantation in regenerative dentistry.

Methods

We conducted a single-center, randomized tr

SUBMITTER: Chen FM 

PROVIDER: S-EPMC4761216 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature