The distribution of cutaneous metastases correlates with local immunologic milieu.

ABSTRACT:

Background

Metastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood.

Objective

We aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites.

Methods

We retrospectively identified all biopsy specimens of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal-appearing skin samples (n = 140), we measured the density of regulatory T cells, CD4(+) effector T cells, and CD8(+) T cells by flow cytometry.

Results

Per unit

SUBMITTER: Schulman JM 

PROVIDER: S-EPMC4761273 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature