Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model.

ABSTRACT:

Rationale

There is significant interest in the NMDA receptor antagonist ketamine due to its efficacy in treating depressive disorders and its induction of psychotic-like symptoms that make it a useful tool for modeling psychosis.

Objective

The present study extends the successful development of an apparatus and methodology to conduct pharmacological MRI studies in awake rhesus monkeys in order to evaluate the CNS effects of ketamine.

Methods

Functional MRI scans were conducted in four awake adult female rhesus monkeys during sub-anesthetic intravenous (i.v.) infusions of ketamine (0.345 mg/kg bolus followed by 0.256 mg/kg/h constant infusion) with and without risperidone pretreatment (0.06 mg/kg). Statistical parametric maps of ketamine-induced blood oxygenation level

SUBMITTER: Maltbie E 

PROVIDER: S-EPMC4761287 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature