The Haptoglobin genotype predicts cardio-renal mortality in type 1 diabetes.

ABSTRACT:

Aims

The Haptoglobin (HP) 2-2 genotype increases cardiovascular diabetes complication incidence. In type 1 diabetes, HP 2-2 also predicts declining kidney function and end-stage renal disease. We investigated whether HP 2-2 predisposes to cardio-renal mortality, while considering other causes of death as competing risks.

Methods

Individuals with type 1 diabetes and HP data available (n=486; mean baseline age, 27 and duration, 19 years) were selected for study. Vital status was assessed as of 8/31/2014. The underlying cause of death was determined and classified based on standardized procedures.

Results

During 25 years of follow-up, 79 (16.3%) cardio-renal deaths and 43 (8.8%) deaths related to other causes occurred. Although total mortality did not differ by HP (25.4%

SUBMITTER: Costacou T 

PROVIDER: S-EPMC4761325 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature