Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis.

ABSTRACT: Vaccine-induced antibodies may wane more quickly in persons living with human immunodeficiency virus (HIV) than in healthy individuals. We reviewed the literature on vaccines routinely recommended in HIV-infected patients to estimate how seroprotection decreases over time in those who initially responded to immunization. For each study retrieved from the literature, the decrease of seroprotection was modeled with a log binomial generalized linear model, and data were pooled in a meta-analysis to provide estimates of seroprotection 2 and 5 years after the last vaccine administration. Our analyses confirmed that the duration of seroprotection was shorter in HIV-infected patients and that with current guidelines, a substantial proportion of patients would have lost protective antibodies befor

SUBMITTER: Kerneis S 

PROVIDER: S-EPMC4761378 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature