Future directions in the treatment of osteosarcoma.

ABSTRACT:

Purpose of review

Overall survival rates for osteosarcoma have remained essentially unchanged over the past 3 decades despite attempts to improve outcome via dose intensification and modification based on response. This review describes recent findings from contemporary clinical trials, advances in the comprehension of osteosarcoma biology and genomic complexity, and potential opportunities using targeted and immune-mediated therapies.

Recent findings

Recent results from international collaborative trials have failed to demonstrate an ability to improve outcomes using a design in which the randomized question is dictated based on histologic response to preoperative chemotherapy. Novel prognostic markers assessable at diagnosis are vital to identifying subsets of osteosarcoma

SUBMITTER: Bishop MW 

PROVIDER: S-EPMC4761449 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature