Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn.

ABSTRACT:

Importance

The association between selective serotonin reuptake inhibitor (SSRI) antidepressant use during pregnancy and risk of persistent pulmonary hypertension of the newborn (PPHN) has been controversial since the US Food and Drug Administration issued a public health advisory in 2006.

Objective

To examine the risk of PPHN associated with exposure to different antidepressant medication classes late in pregnancy.

Design and setting

Cohort study nested in the 2000-2010 Medicaid Analytic eXtract for 46 US states and Washington, DC. Last follow-up date was December 31, 2010.

Participants

A total of 3,789,330 pregnant women enrolled in Medicaid from 2 months or fewer after the date of last menstrual period through at least 1 month after delivery. The source coho

SUBMITTER: Huybrechts KF 

PROVIDER: S-EPMC4761452 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature