Airway Hypersensitivity, Reflux, and Phonation Contribute to Chronic Cough.

ABSTRACT:

Background & aims

Although chronic cough is common, its etiology is often elusive, making patient management a challenge. Gastroesophageal reflux and airway hypersensitivity can cause chronic cough. We explored the relationship between reflux, phonation, and cough in patients with idiopathic chronic cough.

Methods

We performed a blinded, cross-sectional study of nonsmoking patients with chronic cough (duration, >8 weeks) refractory to reflux treatment referred to the Digestive Disease Center at Vanderbilt University. All underwent 24-hour acoustic recording concurrently and temporally synchronized with ambulatory pH-impedance monitoring. Cough, phonation, and pH-impedance events were recorded. We evaluated the temporal relationship between cough and phonation or reflux event

SUBMITTER: Francis DO 

PROVIDER: S-EPMC4761487 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature