Moving towards personalised therapy in head and neck squamous cell carcinoma through analysis of next generation sequencing data.

ABSTRACT: Personalised medicine tumour boards, which leverage genomic data to improve clinical management, are becoming standard for the treatment of many cancers. This paper is designed as a primer to assist clinicians treating head and neck squamous cell carcinoma (HNSCC) patients with an understanding of the discovery and functional impact of recurrent genetic lesions that are likely to influence the management of this disease in the near future. This manuscript integrates genetic data from publicly available array comparative genome hybridization (aCGH) and next-generation sequencing genetics databases to identify the most common molecular alterations in HNSCC. The importance of these genetic discoveries is reviewed and how they may be incorporated into clinical care decisions is discussed. Cons

SUBMITTER: Giefing M 

PROVIDER: S-EPMC4761501 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature