Association between complement factor I gene polymorphisms and the risk of age-related macular degeneration: a Meta-analysis of literature.

ABSTRACT:

Aim

To systematically review the association between complement factors I (CFI) polymorphisms and age-related macular degeneration (AMD) and to explore whether CFI polymorphisms are associated with AMD.

Methods

Meta-analysis of articles published from 1995 to January 2015 of articles involved with AMD and polymorphisms of the CFI gene. Eligible data were pooled in a Meta-analysis, analyzing using STATA software (version 12.0), Review Manager (version 5.2) and different models based on the heterogeneity of effect sizes. Egger's test, Begg's rank correlation methods were used to evaluate for publication bias.

Results

Thirteen articles were eligible, describing two loci polymorphisms of the CFI gene (of which 12 articles focus on rs10033900T>C and 3 articles focus on rs2

SUBMITTER: Wang Q 

PROVIDER: S-EPMC4761747 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature