Association Between Three SNPs and Thromboangiitis Obliterans in Xinjiang Uyghur Population.

ABSTRACT:

Background

Thromboangiitis obliterans (TAO), also called Buerger's disease, is a chronic peripheral vascular occlusive disease. It is an obliterative vasculitis characterized by arterial thrombosis and strongly associated with tobacco exposure. The pathogenesis and etiology of TAO are not well understood, but genetic factors may be important in its development. A case-control study was undertaken to identify genetic factors potentially involved in the pathogenesis of TAO in a Xinjiang Uyghur population of China, where TAO is common.

Methods

We ascertained 177 TAO patients by clinical screening and 86 healthy individuals from the HAPMAP database. The genotypes of single-nucleotide polymorphisms (SNPs) of the participants were identified using the Affymetrix Genome-Wide Human

SUBMITTER: Shi ZF 

PROVIDER: S-EPMC4761799 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature