Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling.

ABSTRACT:

Aims

Recent advances in redox biology have emphasized the role of hydrogen peroxide (H2O2) in the modulation of signaling pathways and revealed that H2O2 plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H2O2 levels in mature tissue would be of great interest.

Results

We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H2O2 levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H2O2 production in the wounded epidermis. Finally, we show that H2O2 and nerve growth are regulated via reciprocal action in adults.

Innovati

SUBMITTER: Meda F 

PROVIDER: S-EPMC4761803 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature