Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.

ABSTRACT: Linkage mapping studies in model organisms have typically focused their efforts in polymorphisms within coding regions, ignoring those within regulatory regions that may contribute to gene expression variation. In this context, differences in transcript abundance are frequently proposed as a source of phenotypic diversity between individuals, however, until now, little molecular evidence has been provided. Here, we examined Allele Specific Expression (ASE) in six F1 hybrids from Saccharomyces cerevisiae derived from crosses between representative strains of the four main lineages described in yeast. ASE varied between crosses with levels ranging between 28% and 60%. Part of the variation in expression levels could be explained by differences in transcription factors binding to polymorphic

SUBMITTER: Salinas F 

PROVIDER: S-EPMC4761897 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature