A large-scale perspective on stress-induced alterations in resting-state networks.

ABSTRACT: Stress is known to induce large-scale neural modulations. However, its neural effect once the stressor is removed and how it relates to subjective experience are not fully understood. Here we used a statistically sound data-driven approach to investigate alterations in large-scale resting-state functional connectivity (rsFC) induced by acute social stress. We compared rsfMRI profiles of 57 healthy male subjects before and after stress induction. Using a parcellation-based univariate statistical analysis, we identified a large-scale rsFC change, involving 490 parcel-pairs. Aiming to characterize this change, we employed statistical enrichment analysis, identifying anatomic structures that were significantly interconnected by these pairs. This analysis revealed strengthening of thalamo-corti

SUBMITTER: Maron-Katz A 

PROVIDER: S-EPMC4761902 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature