Effect of diabetic duration on hemorheological properties and platelet aggregation in streptozotocin-induced diabetic rats.

ABSTRACT: Diabetes mellitus with abnormal glucose concentration is associated with changes in hemorheological properties, endothelial function, and platelets hyperactivity. Disturbances may significantly be responsible for diabetes-related vascular complications. In this study, hemorheological and hemodynamic properties were measured according to diabetic duration after streptozotocin treatment in rats. For ex vivo measurements, an extracorporeal model was adopted. Flow rate and blood viscosity were measured using a microfluidic device. Erythrocyte aggregation and morphological parameters of erythrocytes were measured by modified erythrocyte sedimentation rate and the phase-contrast holography under in vitro conditions. The platelet aggregation and mean pressure in the femoral artery were estimated

SUBMITTER: Yeom E 

PROVIDER: S-EPMC4762006 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature