Continuous neuromonitoring using transcranial Doppler reflects blood flow during carbon dioxide challenge in primates with global cerebral ischemia.

ABSTRACT:

Objective

At present, there is no consensus on the optimal monitoring method for cerebral blood flow (CBF) in neurointensive care patients. The aim of the present study was to investigate whether continuous transcranial Doppler (TCD) monitoring with modulation of partial pressure of CO2 reflects CBF changes. This hypothesis was tested in 2 pathological settings in which cerebral ischemia can be imminent: after an episode of cerebral ischemia and during vasospasm after subarachnoid hemorrhage.

Methods

Sixteen cynomolgus monkeys were divided into 3 groups: 1) chemoregulation in control animals to assess the physiological range of CBF regulation, 2) chemoregulation during vasospasm after subarachnoid hemorrhage, and 3) chemoregulation after transient cerebral ischemia. We surgi

SUBMITTER: Schatlo B 

PROVIDER: S-EPMC4762033 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature