Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis.

ABSTRACT: Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an important contributor to the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell dysfunction, in its broadest sense, encompasses a constellation of various nonadaptive alterations in functional phenotype, which have important implications for the regulation of hemostasis and thrombosis, local vascular tone and redox balance, and the orchestration of acute and chronic inflammatory reactions within the arterial wall. In this review, we trace the evolution of the concept of endothelial cell dysfunction, focusing on recent insights into the cellular and molecular mechanisms that underlie its pivotal roles in atherosclerotic lesion initiation and progression; explore its relationsh

SUBMITTER: Gimbrone MA 

PROVIDER: S-EPMC4762052 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature