Correlates of obesity-related chronic ventilatory failure.

ABSTRACT:

Introduction

Only a third of obese patients develop chronic ventilatory failure. This cross-sectional study assessed multiple factors potentially associated with chronic ventilatory failure.

Materials/patients and methods

Participants had a body mass index (BMI) >30 kg/m(2), with or without chronic ventilatory failure (awake arterial partial pressure of carbon dioxide >6 kPa or base excess (BE) ≥2 mmols/L). Factors investigated were grouped into domains: (1) obesity measures, (2) pulmonary function, (3) respiratory and non-respiratory muscle strength, (4) sleep study derivatives, (5) hypoxic and hypercapnic responses, and (6) some hormonal, nutritional and inflammatory measures.

Results

71 obese participants (52% male) were studied over 27 months, 52 (SD 9) years and

SUBMITTER: Manuel AR 

PROVIDER: S-EPMC4762144 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature