Multiscale modelling of solid tumour growth: the effect of collagen micromechanics.

ABSTRACT: Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre-fibre and tumour-fibre interactions. We hypothesise that such a model, which provides a purely mechanical description of tumour-host interactions, can be used to explain experimental observations of the effect of collagen micromechanics on solid tumour growth. The model was specified to mouse tumour data, and numerical simulations were performed. The multiscale model produced lower stresses than an equivalent continuum-like approach, due to a more realistic remodelling of the collagen microstructure. Furthermore, solid tumour growth was found to cause a passive mechanical realignment of fibres at the tumour b

SUBMITTER: Wijeratne PA 

PROVIDER: S-EPMC4762195 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature