Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine.

ABSTRACT:

Background

The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants and children. We investigated whether the vaccine efficacy was specific to certain parasite genotypes at the circumsporozoite protein locus.

Methods

We used polymerase chain reaction-based next-generation sequencing of DNA extracted from samples from 4985 participants to survey circumsporozoite protein polymorphisms. We evaluated the effect that polymorphic positions and haplotypic regions within the circumsporozoite protein had on vaccine efficacy against first episodes of clinical malaria within 1 year after vaccination.

Results

In the per-protocol group of 4577 RTS,S/AS01-vaccinate

SUBMITTER: Neafsey DE 

PROVIDER: S-EPMC4762279 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature