Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

ABSTRACT:

Objective

To characterize the cognitive and neuropsychiatric symptoms of patients with behavioral variant frontotemporal dementia (bvFTD) over the natural course of the disease.

Methods

We examined the initial and subsequent neuropsychological test performance and neuropsychiatric symptoms in a large cohort of patients with bvFTD (n = 204) across progressive stages of disease as measured by the Clinical Dementia Rating (CDR). We also compared cognitive and neuropsychiatric impairments of patients with bvFTD to those of an age-matched cohort with Alzheimer disease (AD) dementia (n = 674).

Results

At the earliest stage (CDR = 0.5), patients with bvFTD had profound neuropsychiatric disturbances, insensitivity to errors, slower response times, and poor naming, with intact

SUBMITTER: Ranasinghe KG 

PROVIDER: S-EPMC4762418 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature