Whole-brain MRI phenotyping in dysplasia-related frontal lobe epilepsy.

ABSTRACT:

Objective

To perform whole-brain morphometry in patients with frontal lobe epilepsy and evaluate the utility of group-level patterns for individualized diagnosis and prognosis.

Methods

We compared MRI-based cortical thickness and folding complexity between 2 frontal lobe epilepsy cohorts with histologically verified focal cortical dysplasia (FCD) (13 type I; 28 type II) and 41 closely matched controls. Pattern learning algorithms evaluated the utility of group-level findings to predict histologic FCD subtype, the side of the seizure focus, and postsurgical seizure outcome in single individuals.

Results

Relative to controls, FCD type I displayed multilobar cortical thinning that was most marked in ipsilateral frontal cortices. Conversely, type II showed thickening in t

SUBMITTER: Hong SJ 

PROVIDER: S-EPMC4762421 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature