Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media.

ABSTRACT: Cadmium poisoning poses a serious health concern due to cadmium's increasing industrial use, yet there is currently no recommended treatment. The selective coordination of cadmium in a biological environment-i.e. in the presence of serum ions, small molecules, and proteins-is a difficult task. To address this challenge, a combinatorial library of peptoid-based ligands has been evaluated to identify structures that selectively bind to cadmium in human serum with minimal chelation of essential metal ions. Eighteen unique ligands were identified in this screening procedure, and the binding affinity of each was measured using metal titrations monitored by UV-vis spectroscopy. To evaluate the significance of each chelating moiety, sequence rearrangements and substitutions were examined. Analysi

SUBMITTER: Knight AS 

PROVIDER: S-EPMC4762606 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature